The Phytophthora infestans AVR2 Effector Escapes R2 Recognition Through Effector Disordering.
Identifieur interne : 000035 ( Main/Exploration ); précédent : 000034; suivant : 000036The Phytophthora infestans AVR2 Effector Escapes R2 Recognition Through Effector Disordering.
Auteurs : Li-Na Yang [République populaire de Chine] ; Hao Liu [République populaire de Chine] ; Guo-Hua Duan [République populaire de Chine] ; Yan-Mei Huang [République populaire de Chine] ; Shiting Liu [République populaire de Chine] ; Zhi-Guo Fang [République populaire de Chine] ; E-Jiao Wu [République populaire de Chine] ; Liping Shang [République populaire de Chine] ; Jiasui Zhan [République populaire de Chine, Suède]Source :
- Molecular plant-microbe interactions : MPMI [ 0894-0282 ] ; 2020.
Descripteurs français
- KwdFr :
- MESH :
- composition chimique : Protéines intrinsèquement désordonnées.
- génétique : Phytophthora infestans, Protéines intrinsèquement désordonnées.
- parasitologie : Maladies des plantes.
- pathogénicité : Phytophthora infestans.
- Séquence d'acides aminés, Virulence.
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Intrinsically Disordered Proteins.
- chemical , genetics : Intrinsically Disordered Proteins.
- genetics : Phytophthora infestans.
- parasitology : Plant Diseases.
- pathogenicity : Phytophthora infestans.
- Amino Acid Sequence, Virulence.
Abstract
Intrinsic disorder is a common structural characteristic of proteins and a central player in the biochemical processes of species. However, the role of intrinsic disorder in the evolution of plant-pathogen interactions is rarely investigated. Here, we explored the role of intrinsic disorder in the development of the pathogenicity in the RXLR AVR2 effector of Phytophthora infestans. We found AVR2 exhibited high nucleotide diversity generated by point mutation, early-termination, altered start codon, deletion/insertion, and intragenic recombination and is predicted to be an intrinsically disordered protein. AVR2 amino acid sequences conferring a virulent phenotype had a higher disorder tendency in both the N- and C-terminal regions compared with sequences conferring an avirulent phenotype. In addition, we also found virulent AVR2 mutants gained one or two short linear interaction motifs, the critical components of disordered proteins required for protein-protein interactions. Furthermore, virulent AVR2 mutants were predicted to be unstable and have a short protein half-life. Taken together, these results support the notion that intrinsic disorder is important for the effector function of pathogens and demonstrate that SLiM-mediated protein-protein interaction in the C-terminal effector domain might contribute greatly to the evasion of resistance-protein detection in P. infestans.
DOI: 10.1094/MPMI-07-19-0179-R
PubMed: 32212906
Affiliations:
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wicri:level="3"><nlm:affiliation>Key Lab for Biopesticide and Chemical Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Lab for Biopesticide and Chemical Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Fujian Key Laboratory of Plant Virology, Institute of Plant Virology, Fujian Agricultural and Forestry University, Fuzhou, Fujian 350002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Fujian Key Laboratory of Plant Virology, Institute of Plant Virology, Fujian Agricultural and Forestry University, Fuzhou, Fujian 350002</wicri:regionArea><wicri:noRegion>Fujian 350002</wicri:noRegion></affiliation></author><author><name sortKey="Fang, Zhi Guo" sort="Fang, Zhi Guo" uniqKey="Fang Z" first="Zhi-Guo" last="Fang">Zhi-Guo Fang</name><affiliation wicri:level="1"><nlm:affiliation>Xiangyang Academy of Agricultural Sciences, Xiangyang 441057, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Xiangyang Academy of Agricultural Sciences, Xiangyang 441057, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Wu, E Jiao" sort="Wu, E Jiao" uniqKey="Wu E" first="E-Jiao" last="Wu">E-Jiao Wu</name><affiliation wicri:level="3"><nlm:affiliation>Key Lab for Biopesticide and Chemical Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Lab for Biopesticide and Chemical Biology, Ministry of Education, Fujian 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China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Lab for Biopesticide and Chemical Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Fujian Key Laboratory of Plant Virology, Institute of Plant Virology, Fujian Agricultural and Forestry University, Fuzhou, Fujian 350002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Fujian Key Laboratory of Plant Virology, Institute of Plant Virology, Fujian Agricultural and Forestry University, Fuzhou, Fujian 350002</wicri:regionArea><wicri:noRegion>Fujian 350002</wicri:noRegion></affiliation></author><author><name sortKey="Zhan, Jiasui" sort="Zhan, Jiasui" uniqKey="Zhan J" first="Jiasui" last="Zhan">Jiasui Zhan</name><affiliation wicri:level="3"><nlm:affiliation>State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Fujian Agriculture and Forestry University, Fuzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Fujian Agriculture and Forestry University, Fuzhou</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Forest Mycology and Plant Pathology, Swedish University of Agricultural Sciences, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Forest Mycology and Plant Pathology, Swedish University of Agricultural Sciences, Uppsala</wicri:regionArea><wicri:noRegion>Uppsala</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32212906</idno><idno type="pmid">32212906</idno><idno type="doi">10.1094/MPMI-07-19-0179-R</idno><idno type="wicri:Area/Main/Corpus">000235</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000235</idno><idno type="wicri:Area/Main/Curation">000235</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000235</idno><idno type="wicri:Area/Main/Exploration">000235</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The <i>Phytophthora infestans</i> AVR2 Effector Escapes R2 Recognition Through Effector Disordering.</title><author><name sortKey="Yang, Li Na" sort="Yang, Li Na" uniqKey="Yang L" first="Li-Na" last="Yang">Li-Na Yang</name><affiliation wicri:level="3"><nlm:affiliation>Key Lab for Biopesticide and Chemical Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Lab for Biopesticide and Chemical Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Fujian Key Laboratory of Plant Virology, Institute of Plant Virology, Fujian Agricultural and Forestry University, Fuzhou, Fujian 350002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Fujian Key Laboratory of Plant Virology, Institute of Plant Virology, Fujian Agricultural and Forestry University, Fuzhou, Fujian 350002</wicri:regionArea><wicri:noRegion>Fujian 350002</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Hao" sort="Liu, Hao" uniqKey="Liu H" first="Hao" last="Liu">Hao Liu</name><affiliation wicri:level="3"><nlm:affiliation>Key Lab for Biopesticide and Chemical Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Lab for Biopesticide and Chemical Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Fujian Key Laboratory of Plant Virology, Institute of Plant Virology, Fujian Agricultural and Forestry University, Fuzhou, Fujian 350002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Fujian Key Laboratory of Plant Virology, Institute of Plant Virology, Fujian Agricultural and Forestry University, Fuzhou, Fujian 350002</wicri:regionArea><wicri:noRegion>Fujian 350002</wicri:noRegion></affiliation></author><author><name sortKey="Duan, Guo Hua" sort="Duan, Guo Hua" uniqKey="Duan G" first="Guo-Hua" last="Duan">Guo-Hua Duan</name><affiliation wicri:level="3"><nlm:affiliation>Key Lab for Biopesticide and Chemical Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Lab for Biopesticide and Chemical Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Fujian Key Laboratory of Plant Virology, Institute of Plant Virology, Fujian Agricultural and Forestry University, Fuzhou, Fujian 350002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Fujian Key Laboratory of Plant Virology, Institute of Plant Virology, Fujian Agricultural and Forestry University, Fuzhou, Fujian 350002</wicri:regionArea><wicri:noRegion>Fujian 350002</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Yan Mei" sort="Huang, Yan Mei" uniqKey="Huang Y" first="Yan-Mei" last="Huang">Yan-Mei Huang</name><affiliation wicri:level="3"><nlm:affiliation>Key Lab for Biopesticide and Chemical Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Lab for Biopesticide and Chemical Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Fujian Key Laboratory of Plant Virology, Institute of Plant Virology, Fujian Agricultural and Forestry University, Fuzhou, Fujian 350002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Fujian Key Laboratory of Plant Virology, Institute of Plant Virology, Fujian Agricultural and Forestry University, Fuzhou, Fujian 350002</wicri:regionArea><wicri:noRegion>Fujian 350002</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Shiting" sort="Liu, Shiting" uniqKey="Liu S" first="Shiting" last="Liu">Shiting Liu</name><affiliation wicri:level="3"><nlm:affiliation>Key Lab for Biopesticide and Chemical Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Lab for Biopesticide and Chemical Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Fujian Key Laboratory of Plant Virology, Institute of Plant Virology, Fujian Agricultural and Forestry University, Fuzhou, Fujian 350002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Fujian Key Laboratory of Plant Virology, Institute of Plant Virology, Fujian Agricultural and Forestry University, Fuzhou, Fujian 350002</wicri:regionArea><wicri:noRegion>Fujian 350002</wicri:noRegion></affiliation></author><author><name sortKey="Fang, Zhi Guo" sort="Fang, Zhi Guo" uniqKey="Fang Z" first="Zhi-Guo" last="Fang">Zhi-Guo Fang</name><affiliation wicri:level="1"><nlm:affiliation>Xiangyang Academy of Agricultural Sciences, Xiangyang 441057, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Xiangyang Academy of Agricultural Sciences, Xiangyang 441057, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Wu, E Jiao" sort="Wu, E Jiao" uniqKey="Wu E" first="E-Jiao" last="Wu">E-Jiao Wu</name><affiliation wicri:level="3"><nlm:affiliation>Key Lab for Biopesticide and Chemical Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Lab for Biopesticide and Chemical Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Fujian Key Laboratory of Plant Virology, Institute of Plant Virology, Fujian Agricultural and Forestry University, Fuzhou, Fujian 350002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Fujian Key Laboratory of Plant Virology, Institute of Plant Virology, Fujian Agricultural and Forestry University, Fuzhou, Fujian 350002</wicri:regionArea><wicri:noRegion>Fujian 350002</wicri:noRegion></affiliation></author><author><name sortKey="Shang, Liping" sort="Shang, Liping" uniqKey="Shang L" first="Liping" last="Shang">Liping Shang</name><affiliation wicri:level="3"><nlm:affiliation>Key Lab for Biopesticide and Chemical Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Lab for Biopesticide and Chemical Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Fujian Key Laboratory of Plant Virology, Institute of Plant Virology, Fujian Agricultural and Forestry University, Fuzhou, Fujian 350002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Fujian Key Laboratory of Plant Virology, Institute of Plant Virology, Fujian Agricultural and Forestry University, Fuzhou, Fujian 350002</wicri:regionArea><wicri:noRegion>Fujian 350002</wicri:noRegion></affiliation></author><author><name sortKey="Zhan, Jiasui" sort="Zhan, Jiasui" uniqKey="Zhan J" first="Jiasui" last="Zhan">Jiasui Zhan</name><affiliation wicri:level="3"><nlm:affiliation>State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Fujian Agriculture and Forestry University, Fuzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Fujian Agriculture and Forestry University, Fuzhou</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Forest Mycology and Plant Pathology, Swedish University of Agricultural Sciences, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Forest Mycology and Plant Pathology, Swedish University of Agricultural Sciences, Uppsala</wicri:regionArea><wicri:noRegion>Uppsala</wicri:noRegion></affiliation></author></analytic><series><title level="j">Molecular plant-microbe interactions : MPMI</title><idno type="ISSN">0894-0282</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence (MeSH)</term><term>Intrinsically Disordered Proteins (chemistry)</term><term>Intrinsically Disordered Proteins (genetics)</term><term>Phytophthora infestans (genetics)</term><term>Phytophthora infestans (pathogenicity)</term><term>Plant Diseases (parasitology)</term><term>Virulence (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Maladies des plantes (parasitologie)</term><term>Phytophthora infestans (génétique)</term><term>Phytophthora infestans (pathogénicité)</term><term>Protéines intrinsèquement désordonnées (composition chimique)</term><term>Protéines intrinsèquement désordonnées (génétique)</term><term>Séquence d'acides aminés (MeSH)</term><term>Virulence (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Intrinsically Disordered Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Intrinsically Disordered Proteins</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Protéines intrinsèquement désordonnées</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Phytophthora infestans</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Phytophthora infestans</term><term>Protéines intrinsèquement désordonnées</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Maladies des plantes</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Plant Diseases</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Phytophthora infestans</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Phytophthora infestans</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Virulence</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Séquence d'acides aminés</term><term>Virulence</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Intrinsic disorder is a common structural characteristic of proteins and a central player in the biochemical processes of species. However, the role of intrinsic disorder in the evolution of plant-pathogen interactions is rarely investigated. Here, we explored the role of intrinsic disorder in the development of the pathogenicity in the RXLR AVR2 effector of <i>Phytophthora infestans</i>. We found AVR2 exhibited high nucleotide diversity generated by point mutation, early-termination, altered start codon, deletion/insertion, and intragenic recombination and is predicted to be an intrinsically disordered protein. AVR2 amino acid sequences conferring a virulent phenotype had a higher disorder tendency in both the N- and C-terminal regions compared with sequences conferring an avirulent phenotype. In addition, we also found virulent AVR2 mutants gained one or two short linear interaction motifs, the critical components of disordered proteins required for protein-protein interactions. Furthermore, virulent AVR2 mutants were predicted to be unstable and have a short protein half-life. Taken together, these results support the notion that intrinsic disorder is important for the effector function of pathogens and demonstrate that SLiM-mediated protein-protein interaction in the C-terminal effector domain might contribute greatly to the evasion of resistance-protein detection in <i>P. infestans</i>.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">32212906</PMID><DateCompleted><Year>2020</Year><Month>11</Month><Day>12</Day></DateCompleted><DateRevised><Year>2020</Year><Month>11</Month><Day>12</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0894-0282</ISSN><JournalIssue CitedMedium="Print"><Volume>33</Volume><Issue>7</Issue><PubDate><Year>2020</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Molecular plant-microbe interactions : MPMI</Title><ISOAbbreviation>Mol Plant Microbe Interact</ISOAbbreviation></Journal><ArticleTitle>The <i>Phytophthora infestans</i> AVR2 Effector Escapes R2 Recognition Through Effector Disordering.</ArticleTitle><Pagination><MedlinePgn>921-931</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1094/MPMI-07-19-0179-R</ELocationID><Abstract><AbstractText>Intrinsic disorder is a common structural characteristic of proteins and a central player in the biochemical processes of species. However, the role of intrinsic disorder in the evolution of plant-pathogen interactions is rarely investigated. Here, we explored the role of intrinsic disorder in the development of the pathogenicity in the RXLR AVR2 effector of <i>Phytophthora infestans</i>. We found AVR2 exhibited high nucleotide diversity generated by point mutation, early-termination, altered start codon, deletion/insertion, and intragenic recombination and is predicted to be an intrinsically disordered protein. AVR2 amino acid sequences conferring a virulent phenotype had a higher disorder tendency in both the N- and C-terminal regions compared with sequences conferring an avirulent phenotype. In addition, we also found virulent AVR2 mutants gained one or two short linear interaction motifs, the critical components of disordered proteins required for protein-protein interactions. Furthermore, virulent AVR2 mutants were predicted to be unstable and have a short protein half-life. Taken together, these results support the notion that intrinsic disorder is important for the effector function of pathogens and demonstrate that SLiM-mediated protein-protein interaction in the C-terminal effector domain might contribute greatly to the evasion of resistance-protein detection in <i>P. infestans</i>.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Li-Na</ForeName><Initials>LN</Initials><AffiliationInfo><Affiliation>Key Lab for Biopesticide and Chemical Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Fujian Key Laboratory of Plant Virology, Institute of Plant Virology, Fujian Agricultural and Forestry University, Fuzhou, Fujian 350002, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Hao</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Key Lab for Biopesticide and Chemical Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Fujian Key Laboratory of Plant Virology, Institute of Plant Virology, Fujian Agricultural and Forestry University, Fuzhou, Fujian 350002, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Duan</LastName><ForeName>Guo-Hua</ForeName><Initials>GH</Initials><AffiliationInfo><Affiliation>Key Lab for Biopesticide and Chemical Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Fujian Key Laboratory of Plant Virology, Institute of Plant Virology, Fujian Agricultural and Forestry University, Fuzhou, Fujian 350002, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Yan-Mei</ForeName><Initials>YM</Initials><AffiliationInfo><Affiliation>Key Lab for Biopesticide and Chemical Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Fujian Key Laboratory of Plant Virology, Institute of Plant Virology, Fujian Agricultural and Forestry University, Fuzhou, Fujian 350002, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Shiting</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Key Lab for Biopesticide and Chemical Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Fujian Key Laboratory of Plant Virology, Institute of Plant Virology, Fujian Agricultural and Forestry University, Fuzhou, Fujian 350002, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fang</LastName><ForeName>Zhi-Guo</ForeName><Initials>ZG</Initials><AffiliationInfo><Affiliation>Xiangyang Academy of Agricultural Sciences, Xiangyang 441057, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>E-Jiao</ForeName><Initials>EJ</Initials><AffiliationInfo><Affiliation>Key Lab for Biopesticide and Chemical Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Fujian Key Laboratory of Plant Virology, Institute of Plant Virology, Fujian Agricultural and Forestry University, Fuzhou, Fujian 350002, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shang</LastName><ForeName>Liping</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Key Lab for Biopesticide and Chemical Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Fujian Key Laboratory of Plant Virology, Institute of Plant Virology, Fujian Agricultural and Forestry University, Fuzhou, Fujian 350002, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhan</LastName><ForeName>Jiasui</ForeName><Initials>J</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-9250-0157</Identifier><AffiliationInfo><Affiliation>State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Fujian Agriculture and Forestry University, Fuzhou, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Forest Mycology and Plant Pathology, Swedish University of Agricultural Sciences, Uppsala, Sweden.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>06</Month><Day>01</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mol Plant Microbe Interact</MedlineTA><NlmUniqueID>9107902</NlmUniqueID><ISSNLinking>0894-0282</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D064267">Intrinsically Disordered Proteins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D064267" MajorTopicYN="N">Intrinsically Disordered Proteins</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055750" MajorTopicYN="N">Phytophthora infestans</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010935" MajorTopicYN="N">Plant Diseases</DescriptorName><QualifierName UI="Q000469" MajorTopicYN="Y">parasitology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014774" MajorTopicYN="N">Virulence</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">AVR2</Keyword><Keyword MajorTopicYN="N">Phytophthora infestans</Keyword><Keyword MajorTopicYN="N">coevolution</Keyword><Keyword MajorTopicYN="N">effector</Keyword><Keyword MajorTopicYN="N">intragenic recombination</Keyword><Keyword MajorTopicYN="N">intrinsically disordered protein</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>3</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>11</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>3</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32212906</ArticleId><ArticleId IdType="doi">10.1094/MPMI-07-19-0179-R</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li><li>Suède</li></country><region><li>Fujian</li></region><settlement><li>Fuzhou</li></settlement></list><tree><country name="République populaire de Chine"><region name="Fujian"><name sortKey="Yang, Li Na" sort="Yang, Li Na" uniqKey="Yang L" first="Li-Na" last="Yang">Li-Na Yang</name></region><name sortKey="Duan, Guo Hua" sort="Duan, Guo Hua" uniqKey="Duan G" first="Guo-Hua" last="Duan">Guo-Hua Duan</name><name sortKey="Duan, Guo Hua" sort="Duan, Guo Hua" uniqKey="Duan G" first="Guo-Hua" last="Duan">Guo-Hua Duan</name><name sortKey="Fang, Zhi Guo" sort="Fang, Zhi Guo" uniqKey="Fang Z" first="Zhi-Guo" last="Fang">Zhi-Guo Fang</name><name sortKey="Huang, Yan Mei" sort="Huang, Yan Mei" uniqKey="Huang Y" first="Yan-Mei" last="Huang">Yan-Mei Huang</name><name sortKey="Huang, Yan Mei" sort="Huang, Yan Mei" uniqKey="Huang Y" first="Yan-Mei" last="Huang">Yan-Mei Huang</name><name sortKey="Liu, Hao" sort="Liu, Hao" uniqKey="Liu H" first="Hao" last="Liu">Hao Liu</name><name sortKey="Liu, Hao" sort="Liu, Hao" uniqKey="Liu H" first="Hao" last="Liu">Hao Liu</name><name sortKey="Liu, Shiting" sort="Liu, Shiting" uniqKey="Liu S" first="Shiting" last="Liu">Shiting Liu</name><name sortKey="Liu, Shiting" sort="Liu, Shiting" uniqKey="Liu S" first="Shiting" last="Liu">Shiting Liu</name><name sortKey="Shang, Liping" sort="Shang, Liping" uniqKey="Shang L" first="Liping" last="Shang">Liping Shang</name><name sortKey="Shang, Liping" sort="Shang, Liping" uniqKey="Shang L" first="Liping" last="Shang">Liping Shang</name><name sortKey="Wu, E Jiao" sort="Wu, E Jiao" uniqKey="Wu E" first="E-Jiao" last="Wu">E-Jiao Wu</name><name sortKey="Wu, E Jiao" sort="Wu, E Jiao" uniqKey="Wu E" first="E-Jiao" last="Wu">E-Jiao Wu</name><name sortKey="Yang, Li Na" sort="Yang, Li Na" uniqKey="Yang L" first="Li-Na" last="Yang">Li-Na Yang</name><name sortKey="Zhan, Jiasui" sort="Zhan, Jiasui" uniqKey="Zhan J" first="Jiasui" last="Zhan">Jiasui Zhan</name></country><country name="Suède"><noRegion><name sortKey="Zhan, Jiasui" sort="Zhan, Jiasui" uniqKey="Zhan J" first="Jiasui" last="Zhan">Jiasui Zhan</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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